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Quality of End-of-Life Care for Children With Cancer

RecruitingObservational studyHealthy volunteers welcome

Quality of End-of-Life Care for Children With Cancer: A COG Groupwide Observational Study

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Index Child (COG Registered Patient):

  * Must be deceased
  * \< 18 years old at time of death
  * Diagnosed with any oncologic condition
  * History of enrollment on Stratum 1 of APEC14B1, Project:EveryChild

    * Note: history of treatment on a COG therapeutic trial is not required
  * Resided in the United States, including Puerto Rico, as evidenced by most recent address, at the time of death

Bereaved Parent(s):

* Must be a parent, legal guardian, or caregiver (biological or non-biological) of an eligible Index Child enrolled on APEC14B1 with current Consent to Future Contact (e.g., from the APEC14B1 Part B Consent)
* Self-reported confirmation of familiarity with the care received by the Index Child in the last month of their life
* Bereaved parent must understand English or Spanish (written and/or spoken)
* Must be a parent/guardian/key contact from the Index Child's APEC14B1 Future Contact study record or must be referred by one of the APEC14B1 contacts
* Bereaved parent must be \>= 18 years old at the time of ALTE24C1 study enrollment

Regulatory Requirements:

* Bereaved parent must provide verbal or implied informed consent
* For all participants, all institutional, FDA, and NCI requirements for human studies must be met

About the study

This study examines the role of access to care, patient/family interactions with the healthcare system, and stress in explaining variations in quality of end-of-life care. The data collected from this study may help researchers develop a model for identifying patients at risk of low-quality end-of-life care as well as recommendations for potential future interventions.

What is being tested

Sponsor: Children's Oncology Group · Participants: 2,425 · Started: Jul 31, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07412002

Locations in the U.S.

AlabamaChildren's Hospital of Alabama, Birmingham
ArkansasArkansas Children's Hospital, Little Rock
CaliforniaKaiser Permanente-Oakland, Oakland
DelawareAlfred I duPont Hospital for Children, Wilmington
FloridaGolisano Children's Hospital of Southwest Florida, Fort Myers
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Hospital, Orlando
Nemours Children's Clinic - Pensacola, Pensacola
GeorgiaChildren's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
IowaBlank Children's Hospital, Des Moines
MarylandSinai Hospital of Baltimore, Baltimore
MichiganCorewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Bronson Methodist Hospital, Kalamazoo
MissouriChildren's Mercy Hospitals and Clinics, Kansas City
NevadaRenown Regional Medical Center, Reno
New YorkAlbany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Montefiore Medical Center - Moses Campus, The Bronx
OhioRainbow Babies and Childrens Hospital, Cleveland
PennsylvaniaChildren's Hospital of Pittsburgh of UPMC, Pittsburgh
Rhode IslandRhode Island Hospital, Providence
TexasDell Children's Medical Center of Central Texas, Austin
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
VirginiaUniversity of Virginia Cancer Center, Charlottesville
WashingtonProvidence Sacred Heart Medical Center and Children's Hospital, Spokane
WisconsinSaint Vincent Hospital Cancer Center Green Bay, Green Bay

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.