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Healthy Volunteers Enteral Nutrition Study (HEN)

RecruitingHealthy volunteers welcome

Healthy Volunteers Enteral Nutrition Study

Who can join

Ages 18 to 70 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

1. Must be able to read and understand English
2. Must be able to sign a consent form for the study

Exclusion Criteria:

1. BMI \<20 or \>30
2. Unintentional weight loss of \>10% in the last 3-6 months
3. Kidney disease
4. Diagnosis of cirrhosis
5. Taking diuretics
6. Anemia - Hemoglobin \<lower limit of normal in men or \<10 g/dL in women.
7. Taking iron supplements within 2 weeks for Visit 2.1
8. Taking prebiotic or probiotic supplements or any supplement including a multivitamin within 2 weeks of Visit 2.1
9. Taking antibiotics less than 4 weeks prior to Visit 2.1
10. Diarrhea in the 2 weeks prior to Visit 2.1
11. Diabetes mellitus
12. Diagnosis of congestive heart failure
13. Diagnosis of inflammatory bowel disease or celiac disease
14. Bowel resection other than an appendectomy
15. Pregnancy or breastfeeding
16. Intolerance or allergy to nutritional formula, chicken, eggs, apples, banana, potatoes
17. Using protein supplements, including powder added to food or drinks within 2 weeks of Visit 2.1
18. Baseline bowel frequency less than every 2 days or greater than 3 times daily
19. Student or employee of any one of the investigators.
20. Anyone who cannot receive study payment (e.g. visa constraints).
21. Any condition that the investigator feels may limit the volunteer's ability to complete the study protocol.

About the study

This research study is being conducted to determine the effects of enteral nutrition on healthy people. Enteral nutrition for the purpose of this study refers to the use of a specially developed formula taken by mouth that provides all essential nutrition either in the absence of food or to supplement the intake of foods. Enteral nutrition can be used for many reasons, such as to gain or lose weight, to treat food allergies, or to reduce inflammation in certain intestinal diseases. We would like to understand the effects of enteral nutrition in the absence of intestinal inflammation.

What is being tested

Sponsor: James Lewis · Participants: 25 · Started: Jun 17, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07426003

Locations in the U.S.

PennsylvaniaPenn Center for Advance Medicine, University of Pennsylvania, Philadelphia

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.