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Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration
Randomized Controlled Trial of Video-Laryngoscopy Intervention or Direct Laryngoscopy for Delivery of Less Invasive Surfactant Administration for Premature Infants
Who can join
0 Hours – 3 Days · All sexes
Full eligibility criteria
Inclusion Criteria: * Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and/or meeting threshold per unit protocol Exclusion Criteria: * Infants born ≥29 weeks GA or * Infants with known congenital anomalies or * Infants who are determined by the primary care team to receive comfort care only or * Infants who are intubated at any time prior to surfactant administration
About the study
Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?
What is being tested
- Video Laryngoscopy (procedure)
- Direct Laryngoscopy (procedure)
Sponsor: University of Texas Southwestern Medical Center · Participants: 100 · Started: Jun 11, 2026
Contact the study team
- Principal Investigator, MD · Phone: 214-648-3383
Official record on ClinicalTrials.gov — NCT07426016
Locations in the U.S.
| Texas | Parkland Hospital, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.