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Rehab and Mechanical Ventilation
Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction
Who can join
Ages 25 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: Non-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia Exclusion Criteria: Current smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lung expansion Pregnancy Implanted metallic devices within 10 cm of the cervical spine
About the study
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
What is being tested
- Spinal cord stimulation (device)
- Inspiratory Strength Training (behavioral)
- Sham Stimulation (other)
Sponsor: University of Florida · Participants: 16 · Started: Mar 30, 2026
Contact the study team
- Barbara K Smith, PhD, PT · Phone: 352-294-5315
- Ushna Khan, MD · Phone: 352-273-6855
Official record on ClinicalTrials.gov — NCT07427121
Locations in the U.S.
| Florida | University of Florida, Gainesville |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.