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Amygdala Insula Retraining in the Management of Perimenopause Symptoms

Who can join

Ages 38 to 60 · Women

Inclusion Criteria:

* Experiencing perimenopausal symptoms
* Meets STRAW+10 criteria based on self-assessment (-2 to +1c)
* Able to read and understand English
* Access to internet

Exclusion Criteria:

* Pregnancy
* Presence of a severe psychiatric condition requiring immediate clinical intervention
* Uncontrolled thyroid disease or prolactinoma
* Active cancer treatment
* Inability to provide informed consent
* Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion

About the study

The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms.

Our research questions include:

Does AIR reduce overall perimenopausal symptom burden compared to a wait-list control?

Does AIR improve sleep disturbance, vasomotor symptom interference, fatigue, mood, anxiety, and quality of life in perimenopausal individuals?

Are symptom changes associated with improvements in autonomic regulation and sleep parameters, as reflected by exploratory wearable measures including heart rate variability?

What is being tested

• Amygdala and Insula Retraining (AIR) (behavioral)

Sponsor: Chronic Conditions Research Fund · Participants: 160 · Started: Jul 15, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07427459

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.