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Exercise and Carotid Artery Function in Metabolic Syndrome
Identifying Sex-specific Carotid Endothelial Dysfunction in Young Adults With Metabolic Syndrome
Who can join
Ages 18 to 40 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria (MetSyn cohort): * Waist circumference greater than 102 cm (males) or 82 cm (females) * Triglycerides over 150 mg/dL * HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females) * Blood pressure ≥130/85 mmHg * Fasting plasma glucose over 110 mg/dL Inclusion Criteria (Healthy cohort): \- meet age criteria Exclusion Criteria: * Current smoker, defined as more than 5 cigarettes over past 30 days * Current diagnosis or history of: * peripheral vascular disease * hepatic disease * renal disease * lung disease * gastrointestinal disorders/bleeding * hematologic disease * stroke * myocardial infarction * coronary heart disease * congestive heart failure * heart surgery * sleep apnea * autoimmune diseases * traumatic brain injury, concussion, stroke, or seizures * Asthma * Polycystic ovarian syndrome * Type II diabetes * Currently pregnant or breastfeeding * Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives * Hormonal contraceptive use, such as intrauterine device or hormonal implant use * Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography Exclusion Criteria (healthy controls only): * BMI greater than 25 kg/m2 * Blood pressure over 125/80 mmHg * Meeting any MetSyn criteria listed for MetSyn cohort
About the study
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.
What is being tested
- exercise (behavioral)
- Diagnostics (diagnostic test)
- Inhaled CO2-mixed air (other)
Sponsor: University of Wisconsin, Madison · Participants: 48 · Started: Dec 1, 2025
Contact the study team
- Shawn Bolin, MS · Phone: 608-263-6308
- Logan Heenan, BS · Phone: 608-263-6308
Official record on ClinicalTrials.gov — NCT07430839
Locations in the U.S.
| Wisconsin | University of Wisconsin, Madison |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.