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Time to BBVNA Relief

Temporal Trends and Predictors of Clinical Response Following Basivertebral Nerve (BVN) Ablation: A Prospective Observational Cohort Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Diagnosis of chronic axial low back pain with vertebrogenic features
* Scheduled for BVN ablation
* Able to provide informed consent
* Capable of participating in weekly virtual/telephone follow-up for 8 weeks and in- person or remote follow-up at 3 and 6 months through 2 years

Exclusion Criteria:

* Prior spinal neuromodulation therapy (e.g., spinal cord stimulation or intrathecal pump) within the past 6 months
* Active substance use disorder or uncontrolled psychiatric illness that may interfere with participation
* Cognitive impairment limiting ability to complete surveys or provide informed consent
* Pregnancy
* Incarceration or current status as a prisoner

About the study

Basivertebral nerve ablation (BVNA) is a minimally invasive procedure approved for vertebrogenic low back pain. While early studies support its efficacy, real-world evidence is still evolving, particularly regarding the trajectory of pain relief and functional improvement over time, and predictors of clinical response. This study aims to evaluate clinical outcomes longitudinally following BVNA and identify baseline predictors of response.

What is being tested

• Basivertebral nerve ablation (procedure)

Sponsor: Yale University · Participants: 200 · Started: Apr 19, 2024

Contact the study team

• Charles A Odonkor, MD · Phone: 203-767-1555
• Muhammad U Siddique, MD · Phone: 203-668-2772

Official record on ClinicalTrials.gov — NCT07433634

Locations in the U.S.

Conditions

• Low Back Pain
• Back Pain

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.