Home › Spinal Cord Injuries › NCT07433959

Neuromodulation to Improve Grasping Function After SCI

Neuromodulation to Improve Grasping Function After Spinal Cord Injury

Who can join

Ages 18 to 75 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

For individuals with SCI:

* Ages 18-75 years
* Chronic SCI (≥1 year of injury)
* Cervical injury at C8 or above
* Individuals who have MEP responses in at least one FDI muscle

Exclusion Criteria:

* Uncontrolled medical problems including pulmonary or cardiovascular disease
* Premorbid, ongoing major depression or psychosis, altered cognitive status
* History of head injury or stroke
* Metal plate in skull
* History of seizures
* Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs
* Pregnant females
* Individuals who suffer from a spinal cord disease such as spinal stenosis, spinal bifida or herniated cervical

About the study

The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.

What is being tested

• iTBS (other)
• Sham iTBS (other)
• PCMS (other)
• Sham PCMS (other)
• Exercise (behavioral)

Sponsor: State University of New York at Buffalo · Participants: 54 · Started: Apr 1, 2026

Contact the study team

• Hang Jin Jo, PhD · Phone: 716-829-2905

Official record on ClinicalTrials.gov — NCT07433959

Locations in the U.S.

Conditions

• Spinal Cord Injuries

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.