Repeated CBD Administration and Cannabis Outcomes

Inclusion Criteria:

* English-speaking, literate adults,
* Male or female,
* Between the ages of 18-55,
* Body Mass Index from 18.5-32.0 kg/m2,
* Not currently seeking treatment for cannabis or drug use,
* Able to provide written informed consent and perform all study procedures,
* If female, a negative pregnancy test and use of an effective form of contraception during study participation (e.g., oral contraceptive, abstinence, barrier method),
* Negative urine drug test for drugs of abuse (other than cannabis) prior to every Laboratory Session, and
* Otherwise healthy as determined by the investigator based on medical history, physical examination, vital signs, and laboratory chemistries.

Exclusion Criteria:

* Physiologic drug dependence on opioids, benzodiazepines, barbiturates, and/or alcohol that would require medical management,
* Clinically significant acute medical problem (e.g., infection) or chronic medical problem requiring daily medication or ongoing medical care (e.g., hypertension, cardiovascular disease, diabetes, respiratory disorders \[e.g., asthma, COPD\]),
* Current or past history of major psychiatric disorder that would limit ability to participate in the study,
* Use of cannabis exclusively for medical reasons (no recreational use reported),
* Current, unrelenting chronic pain that prevents participation (i.e., unable to sit in chair for 8 hours),
* Currently using daily prescription medications to manage medical conditions or any drug that could interfere with the study, including potent CYP2C9, CYP3A4, or CYP2C19 inducers,
* Clinically significant abnormal ECG (as determined by study physician/cardiologist),
* Clinically significant abnormal laboratory findings,
* History of seizure disorder,
* Clinically significant history of head injuries requiring medical management or long lasting sequalae, and
* Self-report of past 30-day use of synthetic cannabis (i.e., K2, Spice).