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Comparison of Root Canal Desinfection Protocols

Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study

Who can join

Ages 18 to 70 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
* Molar teeth indicated for endodontic treatment.
* Teeth with intact pulp-chamber walls (no extensive coronal destruction).
* Necrotic pulp confirmed by pulp testing.
* Clinical and radiographic evidence of asymptomatic apical periodontitis.

Exclusion Criteria:

* Immature teeth
* Teeth with calcified or obliterated canals
* Teeth with extensive coronal destruction
* Teeth with previous endodontic treatment
* Symptomatic apical periodontitis
* Teeth with periodontal pockets greater than 4 mm
* Patients who have received systemic antibiotics in the last 3 months
* Patients with a history of diabetes or immune impairment
* Pregnant patients

About the study

Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis

What is being tested

• Desinfection device (device)
• Analytical microbiological methods (device)

Sponsor: State University of New York at Buffalo · Participants: 50 · Started: Apr 1, 2026

Contact the study team

• Stephen Lyon, DDS · Phone: (716) 829-6229
• Thamyres Monteiro, MSc · Phone: (716) 829-6199

Official record on ClinicalTrials.gov — NCT07439614

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.