A Study of Mirikizumab Solution (LY3074828) in Healthy Participants

Inclusion Criteria:

* Are overtly healthy males or females as determined by medical evaluation including:

  * medical history
  * physical examination
  * clinical laboratory tests
  * ECG, and
  * vital signs.
* Have clinical laboratory test results at screening and Day -1 within normal reference range.
* Have a body mass index (BMI) within the range of 18.0 to 34.0 kilograms per square meter (kg/m²), inclusive.

Exclusion Criteria:

* Have significant allergies to humanized monoclonal antibodies or known allergies to mirikizumab, related compounds or any components of the formulation, or history of significant atopy.
* Have significant previous or current history of comorbidities capable of significantly altering the absorption, metabolism, or elimination of drugs.
* Have clinically significant multiple or severe drug allergies, or intolerance to topical corticosteroids, or severe post-treatment hypersensitivity reactions.
* Are immunocompromised.
* Intend to use over-the-counter or prescription medication, including herbal medications and traditional medications, within 7 days prior to dosing.
* Have received treatment with biologic agents within 3 months or 5 half-lives, whichever is longer, prior to dosing.
* Have previously received mirikizumab.
* Have an abnormality in the 12-lead electrocardiogram (ECG).
* Have clinically significant abnormalities in blood pressure, pulse rate, or body temperature.
* Have a current or recent acute, active infection.
* Have active tuberculosis (TB), or any history of active TB.