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Magnetoencephalography (MEG) Pilot Study

Network Characteristics in Essential Tremor (ET) Patients Undergoing High-Intensity Focused Ultrasound (HiFU): a Magnetoencephalography (MEG) Pilot Study

Who can join

Ages 50 to 84 · All sexes

Inclusion:

* Age \>50 years and \<85 years
* Refractory to at least 2 first line tremor medications
* Skull Density Ratio (SDR) \> = 0.35

Exclusion:

* MR/MEG incompatible implants and implantable devices (ex: pacemaker)
* Head tremor interfering with MEG recording
* Severe depression and/or anxiety
* Severe cognitive impairment

About the study

The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU). Essential tremor is a movement disorder that causes shaking, usually in the hands, and can make everyday tasks difficult. HiFU is a treatment that uses focused sound waves to target a small area in the brain involved in tremor. In this study, the investigators aim to understand how this treatment affects the brain's networks by using safe, non-invasive tests such as brain imaging, brain wave recordings, and movement assessments.

What is being tested

• MRI and fMRI scans (diagnostic test)
• MEG (diagnostic test)
• Sensor-based motor assessments (diagnostic test)
• Clinical evaluations (other)
• Questionnaires and rating scales that (other)

Sponsor: University of Florida · Participants: 10 · Started: Feb 17, 2026

Contact the study team

• Kerstin Rodriguez, MBBS · Phone: 352-273-9000

Official record on ClinicalTrials.gov — NCT07446192

Locations in the U.S.

Conditions

• Essential Tremor

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.