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Memory Enhancement in Aging With Optimal Dosing

Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation

Who can join

Ages 65 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 65 years of age or older
* normal or corrected-to-normal vision
* color vision

Exclusion Criteria:

* pregnant
* metal implants in head
* implanted electronic devices
* history of neurological problems or head injury
* skin sensitivity
* claustrophobia
* dementia (normal Montreal Cognitive Assessment \> 25)
* depression (normal Geriatric Depression Scale \< 10)
* history of psychosis
* cognitive deficits (MoCA\>25)
* any psychoactive medication

About the study

This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD). We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.

What is being tested

• 1-day patterned tACS (device)
• 3-day patterned tACS (device)
• 5-day patterned tACS (device)
• 1-day continuous tACS (device)
• 3-day continuous tACS (device)
• 5-day continuous tACS (device)

Sponsor: Boston University Charles River Campus · Participants: 240 · Started: Jun 1, 2026

Contact the study team

• Robert Reinhart, PhD · Phone: (617) 353-9481

Official record on ClinicalTrials.gov — NCT07461584

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.