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Serum Inflammatory Protein Concentration During Dental Treatment

Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients

Who can join

Ages 21 to 75 · All sexes

Inclusion Criteria:

* Adults 21-75 years of age
* Systemically healthy
* Non-smoker
* scheduled to receive nonsurgical or surgical periodontal treatment under IV sedation

Exclusion Criteria:

* Patients who have localized form of the disease (less than 30% of available tooth/implant sites are affected with the disease)
* Non-english speaking individuals since informed consent form will be in English only.
* Patients with uncontrolled systemic diseases (such as metabolic diseases, obesity, diabetes, high blood pressure) since these types of chronic inflammatory challenges would cause increase levels of circulatory serum pro-inflammatory markers.
* Pregnant patients (pregnancy will be reported by the patient) since pregnancy itself would affect circulatory serum pro-inflammatory markers.
* Patients who are not willing to have blood drawing for the study purpose.
* Patients who are not willing to sign research related consent form.

About the study

The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:

* How do the levels of inflammatory molecules in the blood change during a periodontal surgery? * How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure? * Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.

What is being tested

• Blood samples for inflammatory markers (other)
• periodontal surgery (procedure)
• Periodontal maintenance (procedure)
• Non-surgical deep cleaning (procedure)

Sponsor: Ohio State University · Participants: 30 · Started: Jul 13, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07468929

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.