MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease
MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease: Effects Of Semaglutide Treatment
Who can join
Ages 12 to 17 · All sexes
Full eligibility criteria
Inclusion Criteria: * participants from the ongoing Mitigation of Cardiovascular Disease Risks in Children with Extreme Obesity (MODERN) study (NCT06967389) * Class 2 or 3 obesity (BMI =120% of the 95th percentile for age and sex) Exclusion Criteria: * Same exclusion as parent study. * Planning to receive or complete dental services during the 12-month course of the study * Ongoing orthodontic treatment * Use of any anti-inflammatory medication (other than steroids) within 1 month prior to enrollment * Currently taking medications that could influence the characteristics or response to periodontal treatment (e.g., use of immunosuppressants or steroids) * Local or systemic antibiotic use within 15 days prior to enrollment or for \>10 days within the past 3 months * History of bleeding disorders * Professional dental prophylaxis or non-surgical periodontal therapy within the past 6 months
About the study
The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity. The main question\[s\] it aims to answer \[is/are\]:
if dental cleaning will improve both oral health and metabolic outcomes beyond the effects of semaglutide alone.
Participants will receive either dental cleaning and oral hygiene instruction or oral hygiene instruction alone.
What is being tested
- Dental Cleaning and Oral Hygiene Instruction (OHI) (procedure)
- Oral Hygiene Instruction (OHI) (behavioral)
Sponsor: Oelisoa Andriankaja · Participants: 50 · Started: Aug 31, 2026
Contact the study team
- Oelisoa Mireille Andriankaja, DDS, MS, PhD · Phone: 8595620597
Official record on ClinicalTrials.gov — NCT07478653
Locations in the U.S.
| Kentucky | University of Kentucky, Lexington |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.