APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)

Inclusion Criteria:

* Patients presenting to the emergency department with left-sided uncomplicated diverticulitis
* Radiologic score (moderate diverticulitis per Ambrosetti classification)
* Age 18-90
* Access to a smartphone with internet access.

Exclusion Criteria:

* Complicated diverticulitis (abscess, free air, peritonitis)- severe diverticulitis by Ambrosetti classification
* Diverticulitis other than left colon
* Contraindication to use of study medication (ie advanced renal failure or allergy to all antibiotics used in the study)
* Concurrent cancer diagnosis
* Concurrent IBD Diagnosis
* Any other disease process with life expectancy \< 6 months
* Concurrent chronic pain diagnosis.
* Women in pregnancy or breastfeeding
* Antibiotic treatment for any reason in the last 3 weeks
* Diagnosis of prior episode of acute diverticulitis in the past 3 months
* Significant comorbidities: diabetes mellitus with organic involvement (retinopathy, angiopathy, nephropathy), emergency assistance for a cardiogenic event in the last 3 months (acute myocardial infarction, angina, heart failure), decompensation of chronic liver disease in the last 3 months (Child ≥ B) and end-stage renal disease.
* Immunodepression: the absence, and immunodepression is the presence, of any of the following: active neoplastic disease, hematologic malignancy, human immunodeficiency virus long-term corticosteroid treatment, immunosuppressant therapy (20mg pred (or equivalent) for \>2 weeks), transplant, splenectomy and genetic immunodeficiency
* Previous colectomy
* Patients with dementia, memory disorders or other cognitive impairment that would impact their ability to provide informed consent or otherwise participate in the trial