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THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health
THRIVE Study: Informing Oral Nicotine Pouch Regulations to Promote Public Health
Who can join
Ages 21 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 21 or older * Able to read and speak English * Willing to abstain from tobacco, nicotine, and marijuana for at least 12 hours prior to study visits * Exclusive use of ONPs (other product use \<10x/mo). * Exhaled CO reading \<10 ppm * Owns a smartphone and can receive SMS text messages with embedded survey links * Negative pregnancy test at V1 and V2 (if applicable) * Uses ≥1.5 cans of ONPs/week * Daily use of ONPs for the past 3 months * At least half of ONPs used are 6mg nicotine concentration. Exclusion Criteria: * Non-English speaker * Individuals currently pregnant, planning to become pregnant, or breastfeeding are excluded due to potential risks associated with nicotine exposure and study procedures (e.g., blood draws). * Individuals with unstable or significant psychiatric conditions are excluded to minimize risk and ensure reliable participation. * Individuals actively attempting to quit nicotine use are excluded to avoid ethical concerns and ensure that study participation does not interfere with cessation efforts * Non-nicotine users and regular tobacco users are excluded from the clinical trial component to ensure that participants have established use patterns appropriate for assessing ONP use behaviors.
About the study
Although nicotine pouches have been gaining popularity over the last few years, little known about how nicotine pouch users actually use these products.
This study will be comprised of adults who use nicotine pouches. If eligible, participants will be asked to complete three study visits and participate in two switching periods where participants use study-provided nicotine pouches.
What is being tested
- Biospecimen Collection (procedure)
- Nicotine Oral Pouch (drug)
- Nicotine Oral Pouch (drug)
- Survey Administration (other)
- Text Message-Based Navigation Intervention (other)
Sponsor: Ohio State University Comprehensive Cancer Center · Participants: 15 · Started: Jun 26, 2026
Contact the study team
- The Ohio State University Comprehensive Cancer Center · Phone: 800-293-5066
Official record on ClinicalTrials.gov — NCT07503925
Locations in the U.S.
| Ohio | Ohio State University Comprehensive Cancer Center, Columbus |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.