Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury

Inclusion Criteria:

* At least 18 years old,
* Stable medical condition,
* Non-progression SCI (no negative change in the neurological level and motor-completeness assess during screening when compared to the neurological status assessed at 6-month period after injury or at least 6 months prior to the screening),
* Motor-complete SCI according to the American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade "A," "B," or "C" above T1 spinal level according to the ASIA International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) Neurological Level of Injury (NLI),
* Sustained SCI at least 12 months prior to entering the study,
* Evidence of symptomatic hypotension as determined by a total score \>0 on the Orthostatic Hypotension Symptom Assessment (OSHA),
* Normal renal function as defined by eGFR \> 59 ml/min/1.73, creatinine value within the range of 0.6-1.2 mg/dl, and BUN values within the range of 7-18 mg/dl,
* Competent to give informed consent for the research protocol,
* Able to understand instructions.

Exclusion Criteria:

* Major pulmonary or cardiovascular disease unrelated to SCI,
* Ventilator dependence,
* Painful musculoskeletal dysfunction that might interfere with testing or stimulation,
* Unhealed fracture that might interfere with testing or stimulation,
* Unhealed contracture that might interfere with testing or stimulation,
* Unhealed pressure sore that might interfere with testing or stimulation,
* Untreated clinically significant depression or psychiatric disorders,
* Ongoing drug abuse,
* Malignancy ,
* Class III obesity (BMI \>40) and at least one co-morbidity thereof: a) Type 2 diabetes as defined by ≥6.5% level on two separate glycated hemoglobin (A1C) tests, b) hypertension as defined by consistent blood pressure readings of ≥140/90 mmHg or taking medication for blood pressure,
* Acute or chronic obstructive deep vein thrombosis,
* Secondary hypotension unrelated to SCI (anemia, hypervolemia, endocrine and neurological diseases),
* Major esophageal/gastrointestinal problem,
* Currently pregnant (females of childbearing potential only),
* Other major medical illness contraindicated for testing or stimulation.