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Pipelle vs the Curved Aspirator Device

The Conventional Pipelle vs the Curved Aspirator Device: a Randomized Controlled Trial

Who can join

Ages 18 to 95 · Women · Healthy volunteers welcome

Inclusion Criteria:

1. Patients \<18- 45 years with risk factors for endometrial cancer requiring endometrial biopsy.
2. Patients ≥ 45 -95 years with abnormal uterine bleeding.
3. Postmenopausal patients with bleeding or suspected endometrial pathology

Exclusion Criteria:

1. Any patient who does not meet the inclusion criteria.
2. Patients with contraindications to endometrial biopsy, including:

   * Pregnancy
   * Acute pelvic inflammatory disease
   * Acute cervical infection
   * Acute vaginal infection
   * Cervical cancer
   * Lack of patient consent

About the study

The primary aim of this study is to rigorously compare the efficacy of two commonly used endometrial sampling devices, the Pipelle and the Miltex, these devices are standard of care at Maimonides. This primary objective is critical, as the ability to accurately reach the uterine cavity is fundamental to obtaining adequate samples for histopathological evaluation, which is crucial for diagnosing endometrial cancer and other uterine pathologies.

What is being tested

• Curved Tip Aspirator (device)
• Pipelle (device)

Sponsor: Jefferson Drapkin · Participants: 124 · Started: Jan 2, 2026

Contact the study team

• Olivia OB/GYN research manager · Phone: 718-283-7962

Official record on ClinicalTrials.gov — NCT07513493

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.