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Vitamin K for Perioperative Warfarin Management
RecruitingPhase 4
Vitamin K Reversal of INR for Perioperative Management of Warfarin: : A Pilot Study to Assess Feasibility
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Warfarin therapy for ≥3 months * Use of home INR testing equipment * Scheduled for a surgical procedure that requires INR ≤ 1.5 (typically achieved with warfarin interruption) * INR ≤ 4 on day 7-10 prior to procedure Exclusion Criteria: * Surgical procedure does not require INR ≤1.5 (typically achieved with warfarin interruption) * Surgical procedure with a high risk of bleeding or complications (urologic procedures, bronchoscopy, epidural injections, nerve blocks, spinal surgery) * Warfarin therapy for \< 3 months * Lack of English language proficiency * Use of a Heartmate II or HVAD left ventricular assist device * Recent thrombotic event (within 3 months) * CHA2DS2-VASc score \>6 * INR \>4 on day 7-10 prior to procedure * Hypersensitivity to any component of Vitamin K or simple syrup (used in the compounding process)
About the study
This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.
What is being tested
- Vitamin K (drug)
- Warfarin (standard without loading) (drug)
- Warfarin (standard with loading) (drug)
Sponsor: University of Michigan · Participants: 20 · Started: Jul 3, 2025
Contact the study team
- Geoffrey Barnes, MD · Phone: 734 936-4000
Official record on ClinicalTrials.gov — NCT07515664
Locations in the U.S.
| Michigan | Michigan Medicine, Ann Arbor |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.