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Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers

Recruiting

Exploring the Feasibility and Acceptability of Brief Mindfulness Training With Vagal Nerve Stimulation for Reducing Alcohol Consumption Among Young Adults

Who can join

Ages 21 to 29 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Currently living in Massachusetts.
* Aged 21-29 years old.
* Consume either more than 14 standard drinks of alcohol per week OR at least 5 standard drinks in one day per week (in past 30 days).
* Have sufficient English fluency to understand procedures and questionnaires.
* Have the capacity and ability to provide informed consent.
* Scores at least 15 points on the PACS at screening. Participants who score between 10 and 14 pts will undergo additional doctoral-level review to assess eligibility.

Exclusion Criteria:

* Current or past diagnosis of a substance use disorder based on the Quick Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) Module C (Substance Use Disorders).
* Active prescription for sedative/hypnotics, opioids, or anesthetic medications.
* Active prescription for medications used to treat alcohol use disorder (AUD), e.g., naltrexone, disulfiram, acamprosate, etc.
* Active psychosis or schizophrenia-spectrum disorder diagnosis.
* Bipolar I disorder history or severe level of mania.
* Severe symptoms of PTSD.
* Acute suicidality or self-injurious behavior.
* Cognitive inability as demonstrated by the inability to complete an informed consent assessment with \>90% accuracy after 2 attempts.
* Current participation in another experimental intervention research study.
* Current daily mindfulness practice \>10 minutes per day.
* Participation in an 8-week intensive Mindfulness-Based Intervention or residential meditation retreat in past 3 years.
* Expected medical hospitalization in the next 2 months; or are currently pregnant.
* Expected incarceration in the next 2 months.
* Presence of electronic implants, such as heart pacemakers, defibrillators, or pumps.
* Presence of a cardiac rhythm disorder.
* History of seizures.
* Presence of skin disorders or malignant diseases in the area in or around the left ear.
* Lack of alcohol craving as assessed by the PACS during screening (score of \< 10 points).

About the study

The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption. All participants will complete a brief (1-week) mindfulness intervention, and participants will be randomized to receive either active or inactive Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) during two in-person laboratory visits. Heart rate variability data and self-report survey data will be collected to assess the impact of the intervention on autonomic regulation, alcohol consumption, and additional clinical measures.

What is being tested

Sponsor: Cambridge Health Alliance · Participants: 50 · Started: Mar 6, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07516873

Locations in the U.S.

MassachusettsCenter for Mindfulness and Compassion, Malden

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.