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Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen

A Randomized Controlled Trial Comparing Suzetrigine and Acetaminophen for Reducing Pain During Local Anesthetic Infiltration and Head Frame Application

Who can join

Ages 21 and older · All sexes

Inclusion Criteria:

* Patients scheduled for a standard of care procedure requiring a stereotactic head frame to be placed

Exclusion Criteria:

* Patients not scheduled for a standard of care procedure requiring a stereotactic head frame to be placed will not be approached

About the study

Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.

What is being tested

• Suzetrigine (drug)
• acetaminophen (drug)

Sponsor: Wake Forest University Health Sciences · Participants: 80 · Started: Jun 22, 2026

Contact the study team

• Wendy Jenkins, BSN RN, CCRC · Phone: 336.716.3842

Official record on ClinicalTrials.gov — NCT07525219

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.