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The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)
A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/Tazobactam or Meropenem: VPT Patient Safety (VPS) Study
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion criteria 1. Hospitalized or being hospitalized. 2. Age \>/=18 yr old. 3. Serious or suspected serious infection for which VPT or VM considered a broad-spectrum combination antibiotic backbone standard of care by clinician. 4. Enrollment can be completed before the first dose of abx (ideally) and no later than before the second dose (alternatively). 5. Consenting/enrollment will not clinically significantly delay abx administration. 6. Baseline and \>/=1 prior Scr available (within 1 yr). 7. Pt or LAR able to provide IC. Exclusion criteria 1\. AKI (\>/=moderate) (KDIGO stage 2-3) (Scr increase \>/=2-fold from chronic BL) (Scr based). 2\. CKD (\>/=moderately to severely decreased eGFR) (KDIGO stage G3b-G5) (by history or eGFR \</=44 mL/min/1.73M2) (Scr based). 3\. Beta lactam allergy. 4. Contraindication to VPT or VM. 5. Infection requiring VPT or VM specifically or another abx regimen. 6. Participation in another research study with interventions that may impact study endpoints.
About the study
The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. Both combinations are approved by the Food and Drug Administration (FDA). The goal is to help doctors know which combination is safer so they can make better choices for their patients.
What is being tested
- Piperacillin + Tazobactam (drug)
- meropenem (drug)
Sponsor: Bassett Healthcare · Participants: 852 · Started: Aug 17, 2026
Contact the study team
- Jennifer Victory, RN, CCRC · Phone: 607-547-6965
Official record on ClinicalTrials.gov — NCT07556107
Locations in the U.S.
| Massachusetts | University of Massachusetts Chan Medical School, Worcester (Not yet recruiting) |
| Nebraska | University of Nebraska Medical Center, Omaha |
| New York | Bassett Medical Center, Cooperstown NY Presbyterian/Queens, Flushing (Not yet recruiting) |
| North Carolina | Wake Forest University Health Sciences, Winston-Salem |
| South Carolina | Medical University of South Carolina - South Carolina Clinical & Translational Research Institute, Charleston |
| West Virginia | West Virginia University, Morgantown |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.