Home › Chronic Cough › NCT07566117
Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough
Recruiting
Identifying Predictors of Treatment Response to Pharmacologic and Nonpharmacologic Interventions in Cough Hypersensitivity Syndrome
Who can join
Ages 18 to 80 · All sexes
Full eligibility criteria
Inclusion Criteria: * Confirmed patient with UNC Health electronic medical record number (MRN) via medical chart review * 18-80 years of age via medical chart review * Completed outpatient clinical encounter within the prior 12 months with a provider in pulmonary medicine, gastroenterology, otolaryngology, and/or allergy at UNC Health via medical chart review, with documentation that chronic cough (lasting 8 weeks or longer) was listed as one of the reasons for the visit, with terminology such as, but not limited to chronic, ongoing, recurrent, persistent, lingering, refractory, longstanding, constant, continual, continuous, prolonged, intermittent, frequent, repetitive, unresolved, non-resolving, habitual, troublesome, bothersome, unmanaged, unexplained, idiopathic, progressive, worsening, treatment-resistant, and/or intractable * Documented provider judgment within the prior 12 months that chronic cough may be at least partially related to cough hypersensitivity via medical chart review, with evidence of at least one of the following: 1) presence of, suspicion of, and/or possible neurogenic component of chronic cough, with terminology such as, but not limited to neurogenic, neuropathic, neurological, sensory neuropathy, vagal neuropathy, sensory nerve dysfunction, cough reflex hypersensitivity, cough hypersensitivity syndrome, upregulated cough reflex, increased cough sensitivity, sensory hyperexcitability, sensory hyperresponsiveness, irritable cough, irritable larynx syndrome, and/or laryngeal sensitivity; and/or 2) currently or previously trialed, offered, considered, and/or recommended treatments for chronic cough typically used for suspected cough hypersensitivity that includes neuromodulating drugs, peripheral nerve block injections, and/or speech therapy * Chronic cough that is bothersome via self-report using a screening questionnaire * Score ≤ 14 on the Patient Health Questionnaire-9 (PHQ-9), indicating no greater than moderate depressive symptom severity (maximum score: 27), via self-report using a screening questionnaire * Score of ≤ 14 on the Generalized Anxiety Disorder-7 (GAD-7), indicating no greater than moderate generalized anxiety symptoms (maximum score: 21), via self-report using a screening questionnaire * Agree to participate in a program to learn new ways to manage chronic cough for 4 weeks via self-report using a screening questionnaire * Able to participate in study activities with a facilitator scheduled during standard weekday business hours via self-report using a screening questionnaire * Access to reliable internet connection and device capable of videoconferencing (e.g., computer, tablet, smartphone) via self-report using a screening questionnaire Exclusion Criteria: * Current smoking status via medical chart review * Unable to read, understand, and speak English without an interpreter via medical chart review * Documented cognitive, intellectual, developmental, or neurological conditions that could interfere with reliable self-report, comprehension, or completion of study procedures via medical chart review
About the study
This study is a prospective, single-center, single-arm pilot trial. The primary research question is whether brief, breath control-focused Acceptance and Commitment Therapy (ACT) is feasible, acceptable, and safe in adults with chronic cough.
What is being tested
- Acceptance and Commitment Therapy (ACT) (behavioral)
Sponsor: University of North Carolina, Chapel Hill · Participants: 30 · Started: Nov 9, 2026
Contact the study team
- Carolyn K. Novaleski, Ph.D., CCC-SLP · Phone: 919-962-5965
Official record on ClinicalTrials.gov — NCT07566117
Locations in the U.S.
| North Carolina | University of North Carolina at Chapel Hill, Chapel Hill |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.