Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome

Rett Syndrome Participants:

Inclusion Criteria:

* Have a clinical diagnosis of classic Rett syndrome
* Have a pathogenic MECP2 genetic variant confirmed via genetic testing
* Are past the clinical regression stage
* Are within the eligible age range for the study (2 years or older)
* Are able to tolerate the noninvasive EEG recording
* Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews

Exclusion Criteria:

* Experiences hearing impairment or hearing loss
* Presence of medical conditions that would prevent safe participation in EEG recording
* Inability to tolerate EEG procedures
* Any condition that in the opinion of the investigator would interfere with study participation or data quality

Controls

Inclusion Criteria:

* Neurologically healthy individuals ages 2 years or older
* Are able to tolerate the noninvasive EEG recording

Exclusion Criteria:

* Experiences hearing impairment or hearing loss
* Medical history of genetic, neurological, or psychiatric disorders
* History of special education services
* Inability to tolerate EEG procedures
* Any condition that in the opinion of the investigator would interfere with study participation or data quality