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Slowly Digestible Carbohydrates for GLP-1 Secretion

Who can join

Ages 18 to 45 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Healthy population
2. BMI between 18.5 and 24.9 kg/m2
3. Adults 18 - 45 years old
4. Men or women
5. Able to read/speak English
6. Fasting blood glucose levels ≤100 mg/dL
7. HbA1c ≤ 5.7%

Exclusion Criteria:

1. Participants with 18 \> Years of Age \> 45 will be excluded.
2. Subjects with 18.5 kg/m² \> BMI \> 24.9 kg/m² will be excluded.
3. Diabetic individuals will be excluded.
4. Individuals with history of gastrointestinal disease will be excluded from the study.
5. Pregnant or nursing women will also be excluded.
6. Individuals taking GLP-1 medications, or on weight-loss diets or restrictive eating patterns.
7. Individuals suffering from dairy or gluten intolerance or allergies will be excluded.

About the study

The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults. In the current study, researchers will observe the amount of SDC that results in clinically meaningful levels of GLP-1, shown by an increase in feelings of fullness and a decrease in hunger, and how long an elevated level of GLP-1 lasts after starch consumption. Researchers aim to address two questions: What amount of SDC maximizes GLP-1-mediated satiety, and does the impact to satiety continue in a second meal? The overall goal is to maximize ileal-digesting SDC's potential use as a food-based agent for weight loss.

Researchers will compare 20, 40, and 60 g of raw corn starch compared to a maltodextrin control on total plasma GLP-1 concentrations, insulin, and blood glucose at baseline and 15, 30, 60, 90, 120, and 180 minutes post-consumption of SDC. Researchers will also measure satiety at baseline, 60, 120, 180 minutes and after a second meal.

There will be a total of 4 study visits with a least a 7-day break between visits. At each study visit, participants will:

* Consume a randomized test beverage (SDC or maltodextrin) * Receive a blood draw at 7 timepoints over 3 hrs * Take a satiety questionnaire 5 times over 3 hrs * Consume a standardized lunch 3 hrs after the test beverage consumption

What is being tested

• Maltodextrin (Placebo) (dietary supplement)
• Raw Corn Starch (dietary supplement)

Sponsor: Purdue University · Participants: 19 · Started: May 1, 2026

Contact the study team

• Bruce R Hamaker, Ph.D. · Phone: 765-494-5668
• Erica de Jong, B.s. · Phone: 7654963802

Official record on ClinicalTrials.gov — NCT07572513

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.