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VEDA Study (DHEA vs Estradiol)
The Use of Vaginal Estrogen vs DHEA in Perimenopausal and Menopausal Women
Who can join
Ages 40 to 90 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Peri- or post-menopausal status * Presence of any genitourinary or vaginal symptom (e.g., dryness, itching, discomfort, dyspareunia) * Willingness and ability to use vaginal therapy * Ability to provide informed consent * English speaker * Ages 40-90 Exclusion Criteria: * Use of systemic hormone therapy within the last 6 months * Gynecologic malignancy * Known allergy to study medications * Active vaginal infection at enrollment * Prior pelvic radiation
About the study
This study is being done to compare two vaginal treatments, vaginal estrogen and vaginal DHEA, that are used to treat vaginal and urinary symptoms related to menopause. These symptoms may include vaginal dryness, discomfort, painful intercourse, or urinary problems and can affect quality of life and sexual health. Women who choose to participate will be randomly assigned to use one of the two treatments for a set period of time. Participants will complete questionnaires about their symptoms and sexual health and have simple vaginal testing at the beginning and end of the study. The goal of this research is to better understand how these treatments affect vaginal health and sexual function so healthcare providers can make informed treatment decisions and improve care for postmenopausal women.
What is being tested
- DHEA ovals (drug)
- Estradiol 0.01% Vag Cream (drug)
Sponsor: University of Arizona · Participants: 324 · Started: Aug 4, 2026
Contact the study team
- Iridian (Iris) Jaramillo, M.S. · Phone: 602-827-2078
- Pamela C Garcia-Filion, MD · Phone: 602-827-2882
Official record on ClinicalTrials.gov — NCT07574216
Locations in the U.S.
| Arizona | Banner University Medical Center Phoenix, Phoenix |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.