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CVFs in SIH: EID vs. PCD CTM

CSF-Venous Fistula Detection in Spontaneous Intracranial Hypotension: Comparative Diagnostic Yields of Energy Integrating Detector Versus Photon Counting Detector CT Myelography

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Adult patient,
2. Confirmed diagnosis of SIH using International Classification of Headache Disorders criteria (third edition), and
3. Brain MRI demonstrating at least one positive imaging finding for SIH (e.g., dural enhancement, venous sinus distention, brain sagging, pituitary engorgement, spontaneous subdural fluid collections).

Exclusion Criteria:

1. Prior treatment of a CVF,
2. Inability to undergo both exams (EID-CTM and PCD-CTM) if needed for diagnosis,
3. Spine MRI demonstrating extradural CSF (confirming CSF leak type other than CVF), and
4. inability to provide informed consent.

About the study

The purpose of this research study is to compare two types of Computed Tomography Myelography (CTM) scans, one on the photon counting detector scanner (called PCD-CTM) and the other on the energy integrating detector scanner (called EID-CTM); both of which doctors usually use to diagnose abnormal connections between the cerebrospinal fluid and the venous system, or CSF-venous fistulas. This study will help to see if the newer PCD-CTM scan can find more spinal fluid leaks \[CSF-venous fistulas (CVF)\] than the scan that is normally used (EID-CTM).

What is being tested

• photon counting detector CT myelography (PCD- CTM) (diagnostic test)
• energy integrating detector CT myelography (EID-CTM) (diagnostic test)

Sponsor: Duke University · Participants: 200 · Started: May 21, 2026

Contact the study team

• Primary Clinical Research Coordinator · Phone: 919-684-7810
• Clinical Research Specialist · Phone: 919-684-3296

Official record on ClinicalTrials.gov — NCT07582744

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.