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A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

A Randomized Trial Comparing Anatomic And Reverse Total Shoulder Replacement For Shoulder Arthritis With An Intact Rotator Cuff

Who can join

Ages 60 to 85 · All sexes

Inclusion Criteria

* Shoulder arthritis
* Intact rotator cuff
* Glenoid retroversion less than 25°

Exclusion Criteria

* Rotator cuff insufficiency
* Fracture deformity/sequelae
* Severe glenoid deformity (C glenoid, severe A2, B2 glenoid)
* Current or previous infection of shoulder
* Previous acromion fracture (not os acromiale)
* Brachial plexopathy
* Axillary neuropathy
* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
* Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
* Medical conditions that would make 2 years follow up unlikely
* Non-English speaking

About the study

The purpose of this study is to determine if patients undergoing anatomic total shoulder arthroplasty (aTSA) will have improved patient reported outcome scores at 1 year compared to those undergoing reverse total shoulder arthroplasty (rTSA).

What is being tested

• aTSA (procedure)
• rTSA (procedure)

Sponsor: Mayo Clinic · Participants: 108 · Started: May 5, 2026

Contact the study team

• Lucille I Anderson, CCRP · Phone: 507-538-5627
• Xavier C Gendry · Phone: 507-266-0687

Official record on ClinicalTrials.gov — NCT07584356

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.