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Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights With Multimodality Imaging

Who can join

Ages 60 and older · All sexes

Inclusion Criteria:

* Patients older than 60 years who have DMR will be included in the study

Exclusion Criteria:

* Patients with prior history of mitral intervention or surgery will be excluded.
* Patient records flagged "break the glass" or "research opt out" will be excluded.
* Persons with allergy to animal dander or animal-instigated asthma will be excluded.

About the study

The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to:

1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term. 2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI 3. Assess patient-reported recovery and quality of life outcomes using validated tools.

The study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.

Sponsor: Cedars-Sinai Medical Center · Participants: 60 · Started: Feb 19, 2025

Contact the study team

• Aakriti Gupta, M.D. · Phone: 267-442-8776

Official record on ClinicalTrials.gov — NCT07605715

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.