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Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis

RecruitingPhase 4

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Male or female volunteers at least 18 years of age and in general good health.
* Willing and able to understand and sign the informed consent form.
* Must have a whole mouth mean TPI score ≥ 3.25
* N=40 must have moderate-severe gingivitis (Whole Mouth Mean MGI≥2.5 or percent bleeding sites based on EBI ≥20%) and N=40 must have mild gingivitis (Whole Mouth Mean MGI≤2.5 and percent bleeding sites based on EBI\<20%)
* Must have at least two areas in the mouth with high plaque/low inflammation and two areas with high plaque/high inflammation
* Be willing to conform to the study protocol and procedures.
* Minimum of 20 natural teeth with scorable facial and lingual surfaces

Exclusion Criteria:

* Medical condition which requires premedication prior to dental visits/procedure.
* Known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredients in the test products as determined by the study examiner.
* Active disease of the hard oral tissues.
* Significant oral soft tissue pathology, excluding plaque-induced gingivitis.
* Subjects with fixed or removable orthodontic appliances or removable partial dentures.
* Dental prophylaxis within 30 days prior to study start.
* Use of antibiotics, antimicrobial drugs, anti-inflammatory drugs, or anticoagulant therapies within 30 days prior to study start.
* Use of chemotherapeutic oral care products within two weeks prior to study start.
* Participation in any other clinical study within 30 days prior to enrollment into this study.
* Subjects who must receive dental treatment during the study dates.
* Immunocompromised individuals (HIV, AIDS, immunosuppressive drug therapy).
* Use of smokeless tobacco, vaping, or e-cigarettes or suspected substance abuse.
* Current smokers (if former smoker, should have stopped at least 1 month prior to Visit 1)
* Pregnant or lactating subjects, or subjects planning to become pregnant during the course of the study.
* Medical condition which prohibits not eating/drinking or chewing gum for four (4) hours prior to your scheduled visits;
* Subjects who have an infectious disease and/or other blood borne diseases (Hepatitis series, HIV, tuberculosis).

About the study

The objective of this clinical research study is to collect and analyze plaque and oral health measures in a population with high plaque/low gingivitis and high plaque/high gingivitis

What is being tested

Sponsor: Colgate Palmolive · Participants: 100 · Started: Apr 20, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07614490

Locations in the U.S.

IndianaSalus Research, Inc., Fort Wayne

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.