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Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage (SAH): a Prospective Observational Study

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adult
* patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage

Exclusion Criteria:

* pregnancy
* pre-existing neurological comorbidities
* coagulation disorders
* anemia
* absence of a good cranial window to perform Transcranial Doppler (TDC)
* presence of \>50% stenosis of carotid arteries confirmed by doppler ultrasound
* Technical problems on EVD that prevent CSF withdrawals

For the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.

About the study

The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).

Sponsor: Massachusetts General Hospital · Participants: 40 · Started: Mar 3, 2024

Contact the study team

• Lorenzo Berra, MD · Phone: 617-726-3030

Official record on ClinicalTrials.gov — NCT07614906

Locations in the U.S.

Conditions

• Subarachnoid Hemorrhage

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.