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Neural Basis of Human Working Memory
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Undergoing SEEG monitoring at Vanderbilt University Medical Center * Age \>18 * English speaking Exclusion Criteria: * Age \<18 * Not able to complete questionnaires (unable to comprehend instructions or follow directions)
About the study
This ClinicalTrials.gov entry corresponds to the Neural Basis of Human Working Memory protocol approved under Vanderbilt University Medical Center IRB #251231.
This study investigates the neural activity underlying human working memory, via local field potential changes (macro level) and/or single neuronal spiking changes (micro level) from depth electrodes placed for invasive seizure monitoring. Subjects will complete neurocognitive tasks while neural recordings are collected. Some patients will complete neurocognitive tasks while stimulation is applied via depth electrodes. Further understanding the neural activity changes underlying normal and impaired working memory may help to identify novel diagnostic methods and treatments for impaired working memory and may support the use of stimulation for treatment of memory disorders.
What is being tested
- Neurocognitive Tasks (behavioral)
- Ripple Neuromed Summit System (device)
Sponsor: Vanderbilt University Medical Center · Participants: 100 · Started: Jun 4, 2025
Contact the study team
- Lucas Chang, BS · Phone: 615-421-3046
- Christos Constantinidis, PhD · Phone: +1 (615) 936-2020
Official record on ClinicalTrials.gov — NCT07617506
Locations in the U.S.
| Tennessee | Vanderbilt University Medical Center, Nashville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.