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Ejaculatory-Sparing HoLEP vs Standard HoLEP

Ejaculatory-sparing Holmium Laser Enucleation of the Prostate (HoLEP) vs Standard HoLEP: a Randomized Controlled Trial

Who can join

Ages 18 to 100 · Men · Healthy volunteers welcome

Inclusion Criteria:

\- Patients who are sexually active with antegrade ejaculation who are undergoing HoLEP for the treatment of bothersome lower urinary tract symptoms.

Exclusion Criteria:

* Patients with pre-existing retrograde ejaculation
* Patients who are not sexually active
* Patients with indwelling urinary catheter prior to surgery, neurological disease, or history of prior prostatic/urethral surgery that may impact ejaculation
* Patients who lack decisional capacity
* Patients unable to read/speak English

About the study

The objective of this study is to compare a new surgical technique for HoLEP that will allow for sparing of ejaculation post-HoLEP.

What is being tested

• Ejaculatory-sparing (ES-sparing) HoLEP (other)

Sponsor: Northwestern University · Participants: 48 · Started: Jun 15, 2026

Contact the study team

• Alyssa McDonald, MPH · Phone: 312-695-8146

Official record on ClinicalTrials.gov — NCT07631286

Locations in the U.S.

Conditions

• Enlarged Prostate (BPH)

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.