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Effect of Gastric Electrical Stimulation on Serum Insulin Levels

Defining the Effect of Gastric Electrical Stimulation on Serum Insulin Levels in Human Subjects

Who can join

Ages 18 to 70 · All sexes

Inclusion Criteria:

* • At least 18 years of age.

  * Documented diagnosis of gastroparesis
  * Not taking diabetic prescribed exogenous insulin.
  * Patient has a GES device that has been implanted for at least 3 months.
  * Willing to give up to 8 blood samples.
  * Willing to lie in a bed for up to 5.5 hours.

Exclusion Criteria:

* • Pregnancy

  * History of allergic reaction to EKG lead placement adhesives.
  * Unable to give informed consent.
  * Unwilling to give up to 8 5 ml blood samples.
  * Unwilling to lie in a bed for up to 5.5 hours.

About the study

The goal of this observational study is to determine how much effect turning the subject's Gastric Electrical Stimulator off for up to four hours will have on levels of insulin, C-peptide, GLP-1 and Glucose levels in patients with gastroparesis who have had a GES for at least three months, who are not taking diabetic prescribed exogenous insulin. EKG recordings will be made and analyzed for Heart Rate Variability and Power Spectral Analysis.

What is being tested

• Gastric Electrical Stimulator (device)

Sponsor: Indiana University · Participants: 32 · Started: Jul 23, 2026

Contact the study team

• Maureen V Schilling, BA · Phone: 3172782064
• Thomas V Nowak, MD · Phone: 3179484272

Official record on ClinicalTrials.gov — NCT07635576

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.