Home › NCT07637630

Trial in HPV Prevention for the U.S. Vietnamese Community

Applying the Multiphase Optimization Strategy to Develop and Test a Culturally-Relevant Digital Health Intervention Targeting HPV Vaccination Among U.S. Vietnamese

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Self-identify as U.S. Vietnamese.
* Are the parent of a youth ages 9-18 who have not initiated the HPV vaccine series. Only one parent per household will be able to participate.
* Have lived in the U.S. for 12 months or more.

Exclusion Criteria:

* Planning to move out of the U.S. within the next 6 months.
* Not fluent in either spoken and written Vietnamese or spoken and written English.
* Inability to provide informed consent.

About the study

The purpose of the HERO study is to leverage the Multiphase Optimization Strategy (MOST) framework to conduct a pilot trial testing four different intervention components (expert video, self-persuasion, narrative storytelling, and motivational interviewing) targeting HPV vaccination among U.S. Vietnamese.

PRIMARY AIM To assess the feasibility and acceptability of each of the four digital HERO intervention components in a pilot optimization trial using the MOST framework. Using a highly efficient design, the study team will randomize 96 Vietnamese parents of unvaccinated adolescents to receive 0 to 4 HERO components. The study team will establish the feasibility (reach, retention, adherence) and acceptability (usability, satisfaction, usefulness, cultural relevance) of each component (expert video, self-persuasion, narrative storytelling, and motivational interviewing).

SECONDARY AIM To investigate effects of each component on HPV vaccination outcomes and psychosocial mediators. The study team will examine the effects on HPV vaccination (initiation and intention) and psychosocial mediators.

What is being tested

• Expert Video (behavioral)
• Self-persuasion (behavioral)
• Narrative Storytelling (behavioral)
• Motivational Interviewing (behavioral)
• Constant Component (behavioral)

Sponsor: Northwestern University · Participants: 96 · Started: May 1, 2026

Contact the study team

• Milkie Vu · Phone: 312-503-6592

Official record on ClinicalTrials.gov — NCT07637630

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.