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VR-Based Cognitive Stimulation Games for Delirium Prevention

Virtual Reality-Based Cognitive Stimulation Games for Enhancing Attention and Preventing Delirium in Older Surgical Patients With Cognitive Impairment

Who can join

Up to age 65 · All sexes

Inclusion Criteria:

* Men and women ≥65 years of age
* Have a pre-existing diagnosis of cognitive impairment (Montreal Cognitive Assessment Score of 15-24)
* Elective or emergency major surgery with the expectation of admission to the Intensive Care Unit following the surgery for three days following surgery

Exclusion Criteria:

* Pre-existing Intubation and invasive ventilation;
* history of severe mental illness;
* admission for a drug overdose;
* severe vertigo;
* history of severe postoperative nausea and vomiting;
* hearing and visual impairment;
* preexisting severe dementia (Montreal Cognitive Assessment Score \< 15; and
* active delirium at the time of screening for eligibility criteria.
* Active suicidal ideation or behavior Screen failure after surgery
* Prolonged intubation after surgery (more than 24 hours)

About the study

This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.

What is being tested

• Virtual Reality Software (other)
• Virtual Reality movies (other)
• Nurse led control arm (other)

Sponsor: The Methodist Hospital Research Institute · Participants: 90 · Started: Apr 24, 2026

Contact the study team

• Hina Faisal, MD · Phone: 346-356-1400

Official record on ClinicalTrials.gov — NCT07641153

Locations in the U.S.

Conditions

• Emergence Delirium
• Delirium

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.