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Congenital Hemolytic and Dyserythropoietic Anemias

Who can join

All ages · All sexes

Inclusion Criteria:

1. Patients who have been diagnosed, by medical history and review of the laboratory data obtained for clinical care, including CBC/reticulocyte count and review of the blood smear, with a hereditary hemolytic anemia, where the genetic etiology is challenging to be identified.
2. Parents and/or grandparents of children that have the above diagnosis. The parents and/or grandparents may or may not have non-immune hemolytic anemia (these will serve as positive or negative inherent controls)

Exclusion:

1\) Patients with anemias known to be acquired and not associated with a genetic etiology.

About the study

The main reason for this research study is to further understand how some red blood cells are formed incorrectly or they have an abnormal metabolism in a way that they break easier in the circulation or during their passage through the spleen.

Participants and/or family members diagnosed with non-immune hemolytic anemia due to a genetic disorder, such as, hemoglobin disorder, erythrocyte membrane skeleton disorders (e.g. spherocytosis, elliptocytosis, or stomatocytosis) or hydration defect (e.g. xerocytosis, overhydrocytosis) or red blood cell (RBC) enzyme disorders, or with a congenital dyserythropoietic anemia (CDA) will be asked to participate.

Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 400 · Started: Jul 25, 2011

Contact the study team

• Amy Shova · Phone: 513-803-1917

Official record on ClinicalTrials.gov — NCT07649213

Locations in the U.S.

Conditions

• Hemolytic Anemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.