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Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

Effects of Fresh Mango as a Table Sugar Replacement on Postprandial Intestinal Permeability and Inflammation Following a High-Sugar Breakfast.

Who can join

Ages 18 to 45 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 18 - 45 years.
* Body mass index between 18.5-35.0 kg/m2
* Not pregnant or expecting to become pregnant (females only)
* Not postmenopausal (females only).
* No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
* No history of using tobacco/illicit drugs
* No history of using glucose-lowering medications/supplements.
* No history of using prescribed anti-inflammatory medications
* Does not use over-the-counter anti-inflammatory medications ≥2x/week
* Does not have a pacemaker.
* No relevant food allergies/intolerances
* Able to lay supine for at least ten minutes.

Exclusion Criteria:

* Not between the ages of 18-45
* Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2
* Pregnant (females only)
* Postmenopausal status (females only).
* Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
* Uses tobacco products or any illicit drugs.
* Uses glucose-lowering drugs/supplements.
* Regularly takes anti-inflammatory drugs (more than 2x week).
* Have a pacemaker.
* Allergic to mango, wheat, gluten, and/or milk.
* Unable to lay in supine position in the dark for at least ten minutes.

About the study

Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.

What is being tested

• High-Glycemic Breakfast Containing Cereal and Fresh Mango (other)
• High-Glycemic Breakfast Containing Cereal and Table Sugar (other)

Sponsor: Ball State University · Participants: 35 · Started: Feb 1, 2026

Contact the study team

• Bryant Keirns, PhD · Phone: 765-285-8356

Official record on ClinicalTrials.gov — NCT07650058

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.