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UHFUS Characterization of Normal Lymphatic Anatomy

Redefining the Normal: Ultra-High Frequency Ultrasound Characterization of Lymphatic Anatomy in Patients With Breast Cancer

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 1\. Aged 18+ at the time of consent.
* 2\. Confirmed breast cancer diagnosis
* 3\. Planned ALND (CPT code: 38745) or SLNB (CPT code: 38900) for breast cancer treatment
* 4\. Provision of a signed and dated informed consent form.
* 5\. Stated willingness to comply with all study procedures and availability for the duration of the study.

Exclusion Criteria:

* 1\. History of transient or permanent edema of the extremity, including edema ≥stage 1 per the International Society of Lymphology (ISL) staging system 15
* 2\. History of prior axillary nodal surgery
* 3\. History of any lymphatic disease or venous disease of the upper extremity, including deep venous thrombosis

About the study

This is a prospective pilot study of breast cancer patients undergoing axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB). Participants will undergo ultra-high frequency ultrasound (UHFUS) imaging with indocyanine green (ICG) dye to map lymphatic channels between the wrist and elbow to investigate normal lymphatic anatomy in patients with breast cancer.

What is being tested

• Indocyanine green (ICG) solution injection (procedure)
• Ultra-High Frequency Ultrasound (device)

Sponsor: University of California, Davis · Participants: 50 · Started: Jun 17, 2026

Contact the study team

• Sheri Nichols · Phone: (916) 734-7289

Official record on ClinicalTrials.gov — NCT07677839

Locations in the U.S.

Conditions

• Breast Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.