Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age less than 18 years-old * Present to rhinology clinic with CRS with nasal polyps * Sense of smell loss for any reason (other than trauma or tumor) Exclusion Criteria: * Patients \< 18 years of age * Individuals with unilateral nasal polyps * Autoimmune diseases * Ciliary disorders * Cystic fibrosis * Smell loss due to tumors or trauma
About the study
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated.
The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.
What is being tested
- Smell Training (other)
Sponsor: The Cleveland Clinic · Participants: 52 · Started: Dec 9, 2025
Contact the study team
- John O'Neill · Phone: 4405062611
- Christopher Novicky · Phone: 216-444-7018
Official record on ClinicalTrials.gov — NCT07681973
Locations in the U.S.
| Ohio | The Cleveland Clinic, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.