Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
RecruitingPhase 2/3
Transcranial Direct Current Stimulation to Treat Aphasia: A Superiority Study
Who can join
Ages 25 to 80 · All sexes
Full eligibility criteria
Inclusion Criteria: * Be willing and able to give informed consent. * Be willing and able to comply with study requirements. * Be between 25 and 80 years of age. * Have used English as the primary language for \> 15 years. * Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan. * Be greater than 6 months post-stroke. * Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \< 9). * Correctly name 140 or fewer items on the PNT. Exclusion Criteria: * History of brain surgery except for during the treatment of the acute stroke. * Seizures during the previous 12-months. * Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection). * Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test). * Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below. * Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators. * Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour. * Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.
About the study
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.
What is being tested
- tDCS (device)
Sponsor: University of South Carolina · Participants: 130 · Started: Jul 14, 2026
Contact the study team
- Leonardo Bonilha · Phone: 803-216-3469
- Julius Fridriksson · Phone: 803-777-5931
Official record on ClinicalTrials.gov — NCT07688551
Locations in the U.S.
| South Carolina | Medical University of South Carolina, Charleston University of South Carolina, Columbia |
| Utah | University of Utah, Salt Lake City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.