Home › Taste and Smell Disorders › NCT07689773

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* Age 18-80
* Self-reported or medically documented smell loss
* Treatment-seeking for their smell loss
* Naïve to TNS
* Able to comprehend English and provide informed consent

Exclusion Criteria:

* Medical Records not available to confirm eligibility
* Documented/Suspected head injury (e.g. sport, accident, blast exposure)
* Neurological disorder (e.g. epilepsy, neurodegenerative disorder)
* Serious mental illness (e.g. schizophrenia, bipolar disorder)
* Suicidal ideation within the last month
* Current (≤6 months) and/or heavy cigarette smokers (i.e. ≥ 10 pack-years)
* Oral/nasal steroids or other intranasal medications
* Immunomodulatory medications
* Pregnant or trying to become pregnant

About the study

Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with standard smell training (ST) to improve olfactory function. Participants will complete 8 weeks of at-home treatment and attend three in-person visits for assessment. Improvements in smell, mood, sleep, and quality of life will be measured.

What is being tested

• Trigeminal Nerve Stimulation-enhanced Smell Training (combination product)

Sponsor: Medical University of South Carolina · Participants: 60 · Started: Jul 10, 2026

Contact the study team

• Bernadette Cortese, PhD · Phone: 8437926922

Official record on ClinicalTrials.gov — NCT07689773

Locations in the U.S.

Conditions

• Taste and Smell Disorders
• Anosmia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.