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ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.
ICU CONNECT Trial: A MultIcenter Comparison Cohort Trial EvalUating the Correlation Between nOn-iNvasive EMG and iNvasive EMG in Healthy Volunteers and Critically Ill PaTients
Who can join
Ages 18 to 90 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Cohort 1: Healthy volunteers Inclusion criteria: * Subjects must be \> 18 years old and \< 90 years old. * Subjects must consent to participate. Cohort 2: Non-intubated critically ill patients Inclusion criteria: * Subjects may be male or female. * Subjects must be \> 18 years old and \< 90 years old. * Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves). Cohort 3: Intubated critically ill patients Inclusion criteria: * Subjects may be male or female. * Subjects must be \> 18 years old and \< 90 years old. * Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves). * For the Subjects in the ICU that are intubated, they must be planned to be intubated for at least 24 hours. * Subjects must be intubated for no longer than ≥ 72 hours before enrollment. Exclusion Criteria: * Cohort 1: Healthy volunteers Exclusion criteria: * Subjects with previous paralysis or neuromuscular disease. * Subjects with spinal cord or brain injuries that impact motor function. * Subjects with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients Exclusion criteria: * Subjects with previous paralysis or neuromuscular diseases. * Subjects with previous peripheral nerve injuries to the tested limbs. * Subjects with spinal cord or brain injuries (including stroke) that impact motor function. * Subjects without a POA or next of kin for those patients that are unable to consent themselves. * Subjects with an allergy to clinical adhesive or hydrogel. Cohort 3: Intubated critically ill patients Exclusion criteria: * Subjects with previous paralysis or neuromuscular disease * Subjects with previous peripheral nerve injuries to the tested limbs. * Subjects with spinal cord or brain injuries that impact motor function. * Subjects without a POA or next of kin for those patients that are in the intubated arm. * Subjects with intubations expected to last less than 24 hours. * Subjects who have already been intubated for \> 72 hours. * Subjects with an allergy to clinical adhesive or hydrogel.
About the study
This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction/EMG tests done by a specialist to see if they match. They will focus on muscle response signals in the hand and leg over about 10 days in three groups: healthy volunteers, ICU patients who are not on ventilators, and ICU patients who are on ventilators.
What is being tested
- TetraGraph (device)
- Electromyography (device)
- Nerve conduction studies (device)
Sponsor: Endeavor Health · Participants: 24 · Started: 2026-06
Contact the study team
- Jessica Brickner · Phone: 847-570-1197
- Nia Moragne · Phone: 847-570-1197
Official record on ClinicalTrials.gov — NCT07699562
Locations in the U.S.
| Illinois | Endeavor Health, Evanston |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.