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Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task

RecruitingObservational studyHealthy volunteers welcome

Cognitive and Motor Function Examination in Patients With Urea Cycle Disorders (UCD) During a Driving Task Using Functional Near Infrared Spectroscopy (fNIRS)

Who can join

Ages 16 to 40 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Individuals 16 to 40 years with molecular or biochemical confirmation of a urea cycle disorder.
* Healthy individuals will serve as an age and sex matched comparison group. Active driver's license for at least 6 months
* Read and understand English. as the tasks have not been validated in other languages
* IQ \>=70.

Exclusion Criteria:

* Skin disease that affects the scalp
* Past or present vascular disease
* Head trauma with loss of consciousness in the last year or evidence of cognitive impairment due to and persisting after head trauma
* Motor movement disorder which may cause excessive movement or impede use of the steering wheel and/or pedal
* Premature birth or birth before 32 weeks of gestation
* The participant is taking a stimulant or antidepressant
* Allergy to any component of the device, although expected to be rare
* History of psychosis
* Self-reported motion or cyber sickness
* Self-reported illicit substance use
* Vision disorder

About the study

This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and attention.

Sponsor: St. Jude Children's Research Hospital · Participants: 60 · Started: Jul 20, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07701694

Locations in the U.S.

TennesseeSt. Jude Children's Research Hospital, Memphis

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.