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NASA Exercise Prebreathe Study

Exercise Prebreathe Study in Healthy Adult Volunteers to Evaluate Risk of Decompression Sickness During Simulated Spacewalk Conditions

Who can join

Ages 30 to 60 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Non-smoking volunteers aged 30-60 years
* Able to meet VO2 peak requirements (\>35 ml/kg/min males, \>30 ml/kg/min females)

Exclusion Criteria:

* Pregnancy
* Lung disease, heart disease, hypertension, or diabetes
* Musculoskeletal pain conditions
* Requirement for regular medications such as analgesics

About the study

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

What is being tested

• Oxygen Prebreathe and Hypobaric Exposure (procedure)

Sponsor: Duke University · Participants: 30 · Started: Aug 13, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07702539

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.