Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg

Inclusion Criteria:

* Adult male and female subjects of any race or ethnicity who are ≥18 years of age.
* Best corrected CL visual acuity of 0.3 Logarithm of the Minimum Angle of Resolution (logMAR) or better in both eyes (Snellen equivalent 20/40).
* Soft 1-day silicone hydrogel CL wearer (daily disposable only)
* Contact Lens Dry Eye Questionnaire (CLDEQ)-8 scores (CLDEQ-8 scores ≥ 12).16
* A VAS score of ≥40 for Eye Dryness and End of Day Contact Lens Discomfort;18, 19
* A corneal fluorescein staining on the original NEI scale of ≥3.
* Habitually wears soft CLs for a minimum of 5 days per week for 6 hours per day during the month prior to enrollment.20
* Willing to maintain habitual CL wear routine for the 3 months duration of the study.20
* Willing to only use Tyrvaya nasal spray prescription dry eye treatment for the 3 months duration of the study.
* Willing to not use any lipid containing artificial tear (AT) for the 3 months duration of the study.
* Willing to only use non-lipid containing preservative free artificial tear for the 3 months duration of the study if needed, but no more than 4 times per day; also must agree to record frequency of daily AT use if applicable.
* Willing to record daily time for CL application, removal, and Tyrvaya applications.
* Habitual CLs have an acceptable fit (good centration, movement, and coverage

Exclusion Criteria:

* Any history of Tyrvaya use within six months of enrollment
* Are currently an overnight CL wearer.
* Are currently wearing rigid gas permeable CLs, scleral CL, hybrid CLs, or reusable soft CLs.
* Have known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome).
* Have a history of ocular surgery within the past 12 months.
* Have a history of viral eye disease.
* Have a history of severe ocular trauma, active ocular infection or inflammation.
* Have ever used using isotretinoin-derivates (e.g., Accutane).
* Are currently taking ocular medications or plan to during the study (e.g., DED, glaucoma, etc).
* Subjects with meibomian gland blockage or significant atrophy (e.g., severe MGD). Currently having \>50% blockage of Meibomian glands in more than two eyelids
* Having blepharitis and/or demodex blepharitis \> grade 1
* Have had a physical meibomian gland dysfunction treatment withing three months of enrollment (iLux, Lipiflow, Radio Frequency and IPL with manual expressions, microblepharoexfoliation etc.).
* Have used a prescription DED or ocular surface disease medication in the last 1 month.
* Have a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation.
* Are pregnant or breast feeding or plan to get pregnant.
* Are a student, employee, or relative of the study team.