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FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids

Furosemide Stress Test Implementation and Outcomes in Critically Ill Children at High Risk for Acute Kidney Injury: A Hybrid Study

Who can join

All ages · All sexes

Inclusion Criteria:

* Admitted to the pediatric intensive care unit (PICU)
* Renal Angina Index (RAI) greater than or equal to 8 (RAI+)
* Urine NGAL greater than or equal to 150 ng/mL (NGAL+)

Exclusion Criteria:

* Receipt of renal replacement therapy prior to PICU admission

About the study

The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney injury (AKI). The main question it aims to answer is: Does implementing the decision support tool reduce fluid overload and help predict which children will receive dialysis?

Researchers will identify children admitted to the pediatric intensive care unit who are at high risk for AKI using risk stratification and biomarker testing, then compare outcomes in the two years after the tool is introduced with the two years before.

What is being tested

• Furosemide Stress Test Clinical Decision Support Tool (other)

Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 120 · Started: May 27, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07718464

Locations in the U.S.

Conditions

• Acute Kidney Injury

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.