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Radiation Therapy and Thymus Function in Young Women With Breast Cancer
Off-Target Effects of Breast Cancer Adjuvant Radiation Therapy on Thymus Function in Young Women
Who can join
Ages 18 to 50 · Women
Full eligibility criteria
Inclusion Criteria: * Women aged 18 to 50 undergoing mastectomy or breast-conserving surgery for breast cancer of any subtype at DUMC and associated satellite centers * Histologic documentation of breast cancer based on pathology * Systemic therapies including hormone therapy, targeted therapy, chemotherapy and immunotherapy as given for breast cancer treatment at the discretion of the treating medical oncologist are allowed and use of such therapies will be documented and included as a covariate * Willing and able to provide written informed consent Exclusion Criteria: * Prior history of therapeutic high-dose irradiation of the thorax (e.g. for treatment of lung cancer, head/neck cancer, Hodgkin disease, etc., not just radiological imaging alone) * History of thymectomy or treatment with immunosuppressive drugs within the past six months * Individuals with rheumatoid arthritis or other autoimmune conditions * Individuals with Down's syndrome * Male patients
About the study
Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast. The goal of this study is to collect blood samples from young women with breast cancer to study the effect of radiation therapy on the thymus gland.
What is being tested
- Blood draw for the laboratory assessment (procedure)
Sponsor: Duke University · Participants: 125 · Started: 2026-09
Contact the study team
- Duke Radiation Oncology Clinical Trials · Phone: (919 668-3726
Official record on ClinicalTrials.gov — NCT07725172
Locations in the U.S.
| North Carolina | Duke Cancer Center, Durham |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.