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Effects of Hard Gum Chewing on Facial Soft Tissue Morphology
The Effect of Intentional Hard Gum Chewing on Facial Morphology: a 3DMD-based Analysis x
Who can join
Ages 20 to 40 · All sexes
Full eligibility criteria
Inclusion Criteria: * Healthy, non-smoking adults. * Age 20 to 40 years. * Presence of a full dentition from central incisor to first molar in all four quadrants, excluding second molars. * Stable occlusion with no ongoing orthodontic treatment or myofunctional therapy. * Ability and willingness to comply with the prescribed hard-gum chewing regimen for 4 weeks and attend all study visits. * Ability to provide written informed consent. Exclusion Criteria: * Age younger than 20 years or older than 40 years. * Evident facial asymmetry from a frontal view. * Signs or symptoms of temporomandibular disorders (TMD) according to the Diagnostic Criteria for TMD (DC/TMD). * Less than the normal range of condylar motion during maximum opening and closing. * Parafunctional habits such as bruxism with pain, clenching, or habitual gum chewing for more than 1 hour per day. * History of major craniofacial trauma, orthognathic surgery, or congenital craniofacial anomalies. * Ongoing orthodontic treatment or recent removal of fixed appliances (\<6 months). * Significant malocclusion or missing teeth in the anterior or premolar-first molar region that may affect mastication. * Systemic diseases or medications affecting muscle or bone metabolism. * Previous use of botulinum toxin (Botox) within the last 6 months or anticipated use during the study period. * Pregnancy or lactation. * Allergy or intolerance to the chewing gum ingredients.
About the study
This pilot clinical trial will evaluate whether intentional chewing of a standardized hard chewing gum for 4 weeks produces measurable changes in facial morphology in healthy adults. Twenty participants aged 20-40 years will undergo three-dimensional facial imaging (3dMD) at baseline (T0), after the 4-week chewing intervention (T1), and following a 4-5-week washout period (T2). Changes in facial soft-tissue morphology will be assessed using three-dimensional surface analysis, including heatmaps, regional surface displacement, and morphometric measurements. Secondary outcomes include self-reported muscle fatigue, soreness, adherence, and temporomandibular disorder (TMD) symptoms.
What is being tested
- Hard Gum Chewing (behavioral)
Sponsor: UConn Health · Participants: 20 · Started: Jun 3, 2026
Contact the study team
- Flavio Uribe (Chair, Depto Orthodontics; UConn School of dental medic · Phone: 860-679-3170
- Georgiana Defilio · Phone: (860) 679-2550
Official record on ClinicalTrials.gov — NCT07726511
Locations in the U.S.
| Connecticut | UConn Health, Farmington |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.